Chicago at Pittsburgh

Pittsburgh is off to a 1-5 start following two games where it allowed a total of 25 runs against the Reds. Now the Pirates face Jake Arrieta, who already beat them on Saturday while giving up a run on six hits in six innings. Chicago won two of three in the season's opening series and Tyler Anderson gave up three runs in five innings. Chicago hitters have a combined .280 batting average and .419 slugging percentage versus Anderson, who had a 12.34 ERA in 11 and 2/3 innings in the month of April, 2019. The Cubs are 23-8 their last 31 games in the first game of a series and the Pirates are 20-42 versus right-handed starters, and 14-41 overall after a loss. Play the Cubs.