Michigan State at Boston College

The Big Ten is an underdog, but its conference power rankings are second in college football while the ACC is fourth. Michigan State has won its first three games with the defense allowing an average of 11.3 points. That includes a 27-24 upset at Maryland in their last road game as a +8.5 underdog. They've won three of their last five straight-up as underdogs of +3, +3.5, and +8.5. Boston College is in a let-down spot after an exhausting game, losing 27-21 at No. 6 Missouri as a +14 underdog. The defense allowed 440 yards, including 176 yards rushing. Last September, they were a double-digit favorite over Holy Cross and squeezed out a 31-28 win, while also losing to Northern Illinois, 27-24, as an 8-point favorite. Play Michigan State on the moneyline.