Iowa State at Oklahoma

Rebuilding Iowa State is still short on defensive depth and talent and that will be exposed against a talented and explosive Oklahoma offense. The Cyclones have played only one road game, at Akron of the MAC, and come off a 17-7 home loss to Texas, a game in which they managed just 10 rushing yards and 256 total yards. The Cyclones are 16-35-2 ATS after accumulating less than 100 yards rushing in their previous game. They face a third-ranked Oklahoma Sooners squad that is tops in the nation in yards (606 per game), fourth in points (48 ppg). Quarterback Baker Mayfield (13 TDs, 0 picks) leads the nation in passing efficiency rating (228.3) and passing yards per attempt (13.2). The Sooners have won 14 consecutive games, as well as 17 consecutive Big 12 contests. They have owned Iowa State, winning 18 straight times and have scored at least 30 points in each game of its current 14-game win streak. And the defense has limited its first four opponents to an average of 198.5 passing yards and 19.5 points per outing. Oklahoma is 45-1-1 straight up in its last 47 meetings with the Cyclones, winning by 10, 36, 45, 38, 15 and 20 points the last six years. Oklahoma is on a 12-5 ATS Big 12 run, with the Cyclones 1-5 ATS in their last six trips to Norman. And Iowa State is 13-31 ATS on the road against teams with winning percentages of 75% or greater. Play Oklahoma.