USC has a winning record and Colorado is 1-4 ATS against teams with winning records. Colorado is coming off its first home loss of the season, a 69-56 setback to #25 UCLA on Jan. 16. It was Colorado's first game without leading scorer Spencer Dinwiddie (14.7 points per game) who tore his left ACL in the game at Washington on Jan. 12. The Buffaloes are 2-6 ATS in their last eight home games vs. a team with a losing road record. Colorado is also on a 1-5 ATS run and the Buffaloes are 1-6-1 ATS in their last eight vs. the PAC-12. Colorado defeated USC 66-60 last year at home in the only meeting between the two teams and this will also be close. Play USC.
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