Oklahoma State at Iowa State

The Big-12 has some of the strongest teams in the country, and when you take to the road against the top 5 teams, it is nearly impossible to get out alive. The top 5 teams in the Big-12 standings own an improbable 73-8 straight up mark, and a big part of that has been the Iowa St. Cyclones who are 14-1 here, with the only loss by arguably the conference's best team Kansas by 7 points. Oklahoma St. since losing 6 straight games has rallied back to win 4 straight, however 3 of those have come at home, and the only road win was at lowly TCU, and they are in for trouble here. Cowboys just 7-19-1 ATS on the road in their last 26 vs a team with a home winning percentage of greater than .600, and overall just 2-9-1 ATS in their last 12 on the road. Make the play on Iowa State.