New York at San Francisco

This is not exactly a marquee Monday Night matchup as the teams have the second-lowest combined winning percentage (.176) for an MNF game played in November or later in NFL history. San Francisco has one potential bright spot as Nick Mullens played well in his first career start, but that's not much for a 2-7 team that is laying points. The 49ers had lost their previous six games and they are #20 in the league in total yards of offense as they keep going through quarterbacks with Jimmy Garoppolo (torn ACL) and C.J. Beathard (concussion) both out. Eli Manning again will try to get his team a win after close losses to Atlanta and Washington. The Giants come off a bye week and have had plenty of time to prepare for this one. Manning was 30-of-47 for 316 yards with a touchdown and two interceptions against the Redskins, but the Giants need to get Saquon Barkley in the mix as he carried 13 times for only 38 yards. New York is 5-0 ATS its last five games after scoring fewer than 15 points its previous game and 7-2 ATS its last nine following an ATS loss. San Francisco is 5-14 ATS its last 19 home games and 3-8 ATS its last 11 after allowing fewer than 15 points its previous game. Take the points with the Giants.