The San Diego Chargers have been a perfect 3-0 in the NFL preseason as they head to the final week on the road in San Francisco vs. the 2-1 49ers. Jim Harbaugh is only in his second year at the helm in San Francisco, and beat the Chargers last year in week four at San Diego. The Niners had a 10-point lead that turned into a 3-point win with a late San Diego score with a minute to play. Phillip Rivers did not take a snap in either of their loss to the Niners in either of the two prior seasons, also game fours. Alex Smith completed 8 of 10 passes for the Niners under Harbaugh last year, enough for the edge here. Play on San Francisco.
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get my free NFL picks and predictions.
Join 413,966 Subscribers!